To God be the glory," an emotional Francis added. 0.80) infection models. The fAUC/MIC targets required to achieve stasis and 1 log kill towards the three strains were 1.89-7.Forty one and 6.98-13.6 within the thigh infection model, respectively, whereas the corresponding values have been 1.57-6.52 and 8.18-42.1 within the lung infection mannequin. Conclusions: This examine indicates the importance of reaching enough time-averaged exposure to colistin and defined target fAUC/MIC values for varied magnitudes of kill. Amplification of resistant subpopulations indicates the importance of investigating rational combinations with colistin. Amplification of colistin-resistant subpopulations was revealed for all strains in each models after 24 h colistin treatment. Strategies: PK/PD of colistin was studied in thigh and lung infection models against A. baumannii ATCC 19606 and two multidrug-resistant clinical isolates (two of the three strains were colistin heteroresistant). Targets: To elucidate the pharmacokinetic/pharmacodynamic (PK/PD) index that predicts colistin efficacy towards Acinetobacter baumannii in neutropenic murine thigh and lung infection models, and to find out the extent of the emergence of resistance in vivo to colistin.

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